The objective of this book is to provide a comprehensive guide to the state of the art technologies and methods applied in the realization of flexible and wearable electronics. The targeted readers of this book include but not limited to college professors, Research and Development scientists, practicing electronics and material engineers, in addition to all the enthusiasts interested in modern technological advancements. Moreover, the book serves as an extensive resource for graduate students working on topics related to wearable and flexible electronics. This book, organized into eleven chapters, introduces the latest research findings and trends related to the design, fabrication processes and techniques used in the realization of wearable and flexible electronics. Chapter Two presents the incremental Latin Hypercube Sampling (LHS) technique which is aimed at speeding up the circuit simulations while considering process variation and aging effects. Two automated robust design optimization techniques are introduced for the analog circuits with flexible Thin Film Transistors.