Saving irrigating water in rice production could help the farmers to reduce the pumping cost and adapt with less fresh water availability in dry season in some regions in the Mekong Delta. The objective of this study was to determine the effect of alternate wetting and drying irrigation (AWD) on soil chemical properties and rice yield in dry season 2014 in the triple rice cropping area in Hoa Binh district, Bac Lieu province. The experiment was designed in completely randomized block, consisting of tree treatments: continous flooding (NT+5), irrigated when when the water depth was -15cm below the soil surface (NT-15) and irrigated when the water depth was -30cm below the soil surface (N-30). The results showed that soil pH and the content of soil available N, vailable P, N uptake and P uptake in straw and grain were not significantly different when when applying AWD compared with continuous continous flooding application. Applying AWD saved about 9 - 19% of irrigated water in comparision with continous irrigation as of farmer's practice. However, soil salinity trended to increase when the field water level dropped below -15 cm. Rice yield in the NT+5 treatment (5,10 tons/ha) was not significantly different as compared to treatments NT-15 (4,87 tons/ha) and NT-30 (4,87 tons/ha). Applying AWD technique in the studied area could help farmer to cope with the fresh water scarcity condition in the dry season and reduce cost for irrigation.