In this paper, we aim to suggest the new concept of well-posedness for the general parametric quasi-variational inclusion problems (QVIP). The corresponding concepts of well-posedness in the generalized sense are also introduced and investigated for QVIP. Some metric characterizations of well-posedness for QVIP are given. We prove that under suitable conditions, the well-posedness is equivalent to the existence of uniqueness of solutions. As applications, we obtain immediately some results of well-posedness for the parametric quasi-variational inclusion problems, parametric vector quasi-equilibrium problems and parametric quasi-equilibrium problems.