Article info.

ABSTRACT

Received 27 Aug 2016
Revised 10 Dec 2016

Accepted 29 Jul 2017

Sperms have main functions of motility and acrosome reaction, they promote their essential role of the oocyte fertilization. Currently, many chemicals are added to the media to enhance sperm quality during artificial insemination. Metformin, commonly used for the treatment of type II diabetes, possesses properties impacting cell metabolism control that has not been assessed yet in sperm. The aims of this experiment were to determine the effects of Metformin on fresh chicken sperm motility and ability to perform acrosome reaction, and evaluate Metformin’s effects on the functions of cryopreserved sperms. Theresults showed that the presence of Metformin in fresh semen has a positive impact on the quality of sperms and helps reducing the gradual decline in sperm motility caused by cryopreservation.

Keywords

Acrosome reaction, AMPK, chicken sperm, Metformin, sperm motility

Cited as: Diep, N.T.M., 2017. Metformin - An agent stimulating motility and acrosome reaction in chicken sperm. Can Tho University Journal of Science. Vol 6: 47-55.