This study sought to discover English listening comprehension problems (Shen, Guizhou, Wichura, Kiattichai, 2007) based on the perceptions (Andrej Démuth, 2012) of English as a Foreign Language (EFL) students in Can Tho University (CTU), Vietnam with an aim to finding out common problems most of the first year English -majored students encountered in listening comprehension. The participants were 126 students  majoring in English studies and were taking the listening and speaking course in the academic year of 2015-2016 at CTU. Data were gathered by means of the questionnaire and interviews. The results of this study showed that psychological states, slang, unfamiliar vocabularies, unfamiliar topics and lack of background knowledge on difficult topics were the major listening comprehension problems faced by the first year English -majored students. Based on the finding, this thesis would suggest some implications for EFL students as well as teachers and also provide a direction for further studies in the same field.