Bighead catfish, Clarias macrocephalus, is an important species for aquaculture. Nevertheless, information on population variation in their reproductive characteristics and larval growth is limited. This research was aimed to evaluate reproductive performance and larval growth of three bighead catfish broodstock strains collected in Ca Mau (CM) and Hau Giang (HG) provinces (wild strain), and Can Tho (CT, domesticated strain). Three groups of fish were cultured under optimal maturation conditions in a recirculating system for three months. Then, 16-18 pairs from each broodstock source were artificially propagated. Relative fecundity differed among sources, from 48,600 (CM) to 69,300 (CT) eggs/kg female (P0.05).