This study is aimed to determine factors affecting local residents’ support on tourism development in Phong Dien district, Can Tho city. Research data from the study were collected from 125 households living in Phong Dien district. Application of Exploratory factor analysis (EFA) and Multiple Linear Regression (MLR), the study results showed that there are five factors affecting local residents’ support on tourism development in Phong Dien including trade-off cost, participation, social utility, attachment and personal utility. In particular, attachment factor has the strongest impact to local peoples’ support on tourism development in Phong Dien district