1-Hexyl-3-3-methylimidazolium bromide ionic liquid (HmimBr) was demonstrated as a good promoting medium for the oxidative cyclization reaction between α- hydroxyacetophenone and 1,2-phenylenediamine to form 2-phenylquinoxaline as the principal product. The optimal conditions involved the use of HmimBr at 100 oC under atmosphere for 180 min in the presence of 3 mol% CuBr as catalyst. Furthermore, HmimBr ionic liquid was successfully recovered and reused for several times with no significant loss in efficiency