This study investigates the perceptions and practices of English as a Foreign Language (EFL) students regarding learning strategies for English for Specific Purposes (ESP) in the context of Political Education. The study focuses on six (6) learning strategies of Oxford (1990)'s classification, including (1) memorization strategies, (2) cognitive strategies, (3) compensation strategies, (4) metacognitive strategies, (5) affective strategies, and (6) social strategies. A mixed-methods approach is employed, including questionnaire and interviews. First, 101 items for the questionnaire are administered to investigate the perception and practice of students on learning strategies. Then interviews with students and teachers are employed to capture more details about the participants’ perception and practice on learning strategies towards ESP for Political Education. The study sample consists of 187 EFL students from School of Political Sciences, Can Tho University, Vietnam who are currently participating in ESP for Political Education course named "Specialized English for Political Education Course 2". The findings reveal that the majority of students have positive perceptions of ESP and recognize the importance of learning strategies in mastering this area.