The effects of elevated salinity (0, 6, 9 and 12 mg L^-1) and temperature (27-28°C, ambient; 31°C; and 34°C) on growth performance and feed utilization were investigated in hybrid red tilapia fingerlings (Oreochromis mossambicus x O. niloticus). The hybrid red tilapia fingerlings had the highest growth rate when reared in freshwater (0 mg L^-1) at ambient, 31°C, or 34°C or when reared in 6 mg L^-1 at 31°C and at 34°C, 9 mg L^-1 at 34°C, or 12 mg L^-1 at 34°C. Rearing fingerlings in freshwater versus higher salinities (9 and 12 mg L^-1) or at higher temperatures did not impact survival rate; however, both feed intake and protein retention were significantly reduced at higher salinities compared to freshwater. Rearing fingerlings at 31°C and 34°C instead of at ambient temperature also increased feed intake significantly. Apparent digestibility coefficient (ADC) of feed in dry matter and proteins was significantly reduced in fingerlings reared in 12 mg L^-1 compared to freshwater while neither ADC metric was affected by temperature. All other assessed indices were unaffected by elevated salinity, elevated temperature, or their interaction. We recommend that hybrid red tilapia fingerlings can be reared at a high temperature of 34°C with elevated salinities of 6-12 mg L^-1.