Comply technological era, logistics services also develop with communication and information technology, it seems to be an effective tool for enterprises in improve quality of goods and sustainable development. Furthermore, businesses are confronted with challenges of resolving efficient logistics services in order to intrigue more potential customers by demonstrating the satisfaction towards logistics services. Thus, the purpose of this article is to assess the satisfaction of small and medium enterprises (SMEs) towards logistics services in the case of Can Tho City and surrounding provinces such as Hau Giang, Vinh Long, An Giang and Kien Giang. By employing SERVQUAL model in exploratory factors analysis (EFA) and regression analysis, the study pointed out that reliability affect positively customers’ satisfaction. Findings from research reveal that there is correlation Reliability factors and the satisfaction of SMEs towards logistics services. Some suggestions for further study in terms of examining in other regions to make comparisons between such places are also addressed.